The male cardiovascular risk profile shifts significantly in the fifties through several converging mechanisms. Clients with persistent nutrient deficiencies despite supplementation often have underlying absorption issues related to gut health. Your gut is where zinc, magnesium, vitamin D, and every other nutrient that supports testosterone production gets absorbed.
Rotter I, Ciosek Ż, Syroka A and Ryl A (2025) A cross-sectional study of testosterone deficiency and inflammatory markers in older men. Moreover, the positive correlation between testosterone and physical activity level suggests that exercise training may reduce the age-related decrease in gonadal androgens, which seems to be one of the main beneficial effects (anti-inflammatory one) of physical activity in aging men. Based on the above literature data, it may be inferred that the correlation between androgens and inflammatory markers observed in this study is not accidental.
For instance, Fernandes et al. (24) reported that individuals who maintained regular physical activity were less likely to exhibit elevated hsCRP levels. Analysis of correlation between anthropometric and hormonal indicators and hsCRp value. Within this analysis, the group’s characteristics were deli eated, showcasing m dian alues, means, and standard deviations, as well as minimum and maximum values.
In the recent comprehensive review on the inflammatory etiology of cardiovascular diseases by Ruscica et al. (2), the role of evaluation of the pro- and anti-inflammatory profiles for appropriate guidelines and treatment of this disease was pointed out. Age-related upregulation of the inflammatory response (described as "inflamm-aging") (1) and the worsening of the blood lipid profile are of great importance because these changes are linked to atherosclerosis, enhanced cardiovascular risk, and the development of metabolic syndrome. Therefore, a low serum T concentration appears to be an independent risk factor in the development of atherosclerosis and cardiovascular diseases. This article was submitted to Translational Endocrinology, a section of the journal Frontiers in Endocrinology Testosterone is the predominant gonadal androgen in men. Federal government websites often end in .gov or .mil. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of int r st
Moreover, fT was calculated using the assumption-free empirical equations (25), as it was shown that this method is very useful in providing more detailed information about the androgen and anabolic/catabolic status of the body (26). Serum TC, TG, and LDL and HDL concentrations were determined with an enzymatic colorimetric method according to the manufacturer’s protocol using the Cobas c501 analyzer (Roche Diagnostics, Mannheim, Germany). The CRP and AAG concentrations were measured using the Siemens-Dade Behring BN ProSpec nephelometer (Marburg, Germany). Because of the aforementioned potential effect of exercise on this relationship, we were also interested in determining the importance of the level of physical activity of the studied subjects on their androgen profile. Far less is known about the possible interactions between testosterone and acute phase proteins C-reactive protein (CRP), ferritin (FER), and alpha-1-acid glycoprotein (AAG), which are all important for inflammatory responses and are frequently assayed in standard laboratory tests. Although the mechanisms of this important outcome of exercise training in aging are at best unclear, one possible explanation lies in the fact that both gonadal androgens and inflammatory status may be affected by the applied training program. On the other hand, an inflammatory process as a manifestation of increased oxidative stress may negatively influence the androgen level (9), both through direct disruption of the reproductive tissue and through the detrimental effect on the regulatory mechanisms of the hypothalamic–pituitary–gonadal (HPG) axis.
C-reactive protein (CRP) levels, a marker of inflammation, may be inversely correlated with testosterone levels in men (2). In patients without TDS, no significant correlation was observed between hsCRP levels and other measured variables. The statistical analysis was car ied out utilizing the Statist ca 13.1 software.
The measurement method for T and C was standardized against the isotope dilution gas chromatography–mass spectrometry (ID GC/MS) reference method. Plasma IL-6 concentration was determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s instruction (R&D Systems, Inc. Minneapolis, MN, USA). All volunteers were fully informed about the aim of this study and gave written consent to take part in the investigation. Ethical approval for the experimental procedures was obtained from the Local Ethical Committee at the Regional Medical Chamber in Krakow, Poland (opinion no. 48/KBL/OIL/2009), and the study protocol was conducted in accordance with the Declaration of Helsinki.
Moreover, it was stated that a change in BMI from "non-obese to obese" may be equivalent to a 15-year fall in the T concentration (32) and that interventions reducing BMI are expected to increase serum T in men (33). They also correspond to the results of Svartberg et al. (30), who reported that the inverse correlation between T and cIMT (carotid intima–media thickness, a marker of artery atherosclerosis) was BMI-dependent. It must also be acknowledged that these results, which are based on correlations, do not infer causation. Moreover, we also determined the relationship between T, fT, and the fT/C ratio and physical activity level.